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Future randomised controlled trials should specifically evaluate the effectiveness of novel AOMs for long-term weight management in older adults with obesity, carefully considering the impact on body composition and functional ability, as well as health economics.

Tirzepatide (Mounjaroand Zepbound), aGLP-1andGIPreceptor agonist, has recently gained significant popularity for itsweight loss benefits

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have an indication for semaglutide.