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These findings were associated with a significant reduction in daily food intake (Extended Data Fig

Besides Semaglutide and Tirzepatide, there are two major next-generation hopefuls backed by industry giantsRetatrutide and CagriSemaalong with Amgens stubborn GIP receptor antagonist theory candidate MariTide, BI/Zealands Survodutide, a novel muscle-building product Bimagrumab, and two domestic second-tier contenders: Innovents Mazdutide and Crown Biosciences Ecnoglutide

doi: 10.1016/j.cmet.2011.01.008

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Placebo groups showed minimal change