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Epac2 interaction with Rim2 and Piccolo is crucial for cAMP-induced Ca 2+ -dependent insulin secretion and is not blocked by inhibition of PKA [493,512,513]
[DOI] [PubMed] [Google Scholar] 49.Tomlinson B, Hu M, Zhang Y, Chan P, Liu ZM
Liddelow et al., 2017)
Some with no prior gastrointestinal disease developed apparently permanent dysfunction
