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Eligible participants included those with early type 2 diabetes who were only being treated using diet and exercise and had a glycated haemoglobin level of between 7% and 9.5%, as well as a body mass index of at least 23

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These effects are typically dose-dependent, most prominent during dose escalation, and tend to diminish over time

To increase the plasma half-life by avoiding renal elimination, GLP-1 analogs were modified by adding acyl groups (liraglutide and semaglutide) or large molecules such as albumin (albiglutide) and the Fc portion of IgG (dulaglutide)

There is emerging evidence to suggest that GLP-1 medications might interact with PMDD symptoms, especially hunger and cravings, which tend to be more pronounced during the luteal phase (the second half of the menstrual cycle)