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With phentermine alone, there have been rare cases of cardiac valvular disease and pulmonary hypertension (high blood pressure of the lungs)

Side effects usually involve gastrointestinal (GI) tract or digestive symptoms

Effect of exenatide therapy on hepatic fat quantity and hepatic biomarkers in type 2 diabetic patients

Semaglutide improves health-related quality of life versus placebo when added to standard of care in patients with type 2 diabetes at high cardiovascular risk (SUSTAIN 6)

GLP-1 has a very brief half-life (less than 2 min) owing to the swift deactivation of the commonly proteolytic enzyme dipeptidyl peptidase-4 (DPP-4), which leads to the emergence of GLP-1 receptor agonists (GLP-1RAs), which are GLP-1 analogs with extended half-lives and ongoing biological activity (Ma et al