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Additional glycemic control is needed increase the dosage to 9 mg orally once daily

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Bupropion carries an FDA black box warning regarding suicidal thoughts in certain populations and is contraindicated for people with seizure disorders or eating disorders

Additionally, patients with inflammatory bowel disease, severe gastroesophageal reflux disease, or other significant gastrointestinal disorders should be monitored closely if treatment is initiated, as the gastrointestinal effects of semaglutide may worsen their underlying condition