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It enrolled 17,604 adults aged 45 or older with a body mass index (BMI) of 27 kg/m2 or greater and preexisting CVD (prior MI, prior stroke or peripheral artery disease) without diabetes

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Less Common but More Serious Risks Although uncommon, semaglutide may be associated with: Pancreatitis Gallbladder problems Kidney complications related to dehydration Changes in blood sugar levels Possible risk of thyroid C-cell tumors (observed in animal studies) Semaglutide is not recommended for individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Berberine in obesity therapy: from molecular mechanisms to clinical applications