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This breaks down the GLP-1 reward signaling mechanism behind that pattern and where the honest limits of the evidence sit.

This review highlights key clinical considerations across reproductive stages, emphasizes the primacy of human exposure data where available, and identifies critical evidence gaps requiring future prospective study.

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In a large randomized withdrawal trial, participants who stopped tirzepatide after substantial initial weight loss regained an average of 14% of their body weight over the following year, while those who continued treatment maintained or furthered their weight loss, with 89.5% keeping at least 80% of their initial weight reduction compared to only 16.6% in the placebo group[3]