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Secondary endpoints measured by meal stimulation included the change from baseline to end of treatment in the 24 h profiles of plasma glucose, glucagon, serum insulin and C-peptide, measured as total AUC 024h during a test day with three standardised meals

GIP receptor engagement increases noticeably

Sterile water has no preservative, so vials reconstituted with it are typically discarded within 24 hours

By acting on both pathways, tirzepatide can have a stronger effect on appetite regulation and blood-sugar control in some people

Semaglutide works by mimicking the action of GLP-1 in the body, enhancing the effects of this hormone