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Understanding this rebound effect helps you make informed decisions about long-term weight management

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It mimics the function of the natural GLP-1 hormone in the body, which is involved in appetite regulation and insulin secretion

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Tirzepatide was associated with greater relative lean body mass (LBM) loss than semaglutide at each measured time point, with excess LBM losses of 1.1%, 1.5%, 1.3% and 2% at 3, 6, 9 and 12 months, respectively

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As of June 2026 it is investigational worldwide

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Stopping Ozempic often leads to rapid weight regain within weeks to months as appetite hormones rebound

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