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2.2 SURMOUNT study program TZP treatment induced a significant BW reduction in diabetic patients who were obese or overweight

doi: 10.1210/en.2013-1934 29 MuscogiuriGDeFronzoRAGastaldelliAHolstJJ

The dose is gradually increased under the guidance of the healthcare provider until the maximum tolerable dose is reached

The rebound is driven by appetite hormone reactivation, not behavioral failure
