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Therefore, the objective of this study was to document the modulation of the IGF axis (IGF-1 and IGFBPs) in severely obese patients undergoing or not a chronic aerobic exercise physical training program after bariatric surgery

A 2024 JAMA Internal Medicine trial led by Thomas Wadden found no clinically meaningful increase in depression or suicidal thoughts among semaglutide users and even a small reduction in depressive symptoms in people without prior psychopathology

By binding to receptors in the pancreas, liver, and gut, semaglutide helps control glucose levels effectively, making it a powerful tool in diabetes treatment

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The STEP UP trial for the 7.2 mg oral Wegovy HD formulation showed approximately 21% average weight loss, approaching the 22.5% seen with injected tirzepatide at 15 mg