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Description
The development of these agents underscores the continuous improvement of the pharmacokinetic and pharmacodynamic profiles of these peptide agents [ Table 1 ], expanding their applications beyond T2DM and obesity to encompass cardiovascular disease event reduction [ Table 2 ]
In both diabetic and non-diabetic patients presenting class II/IV heart failure, GLP-1 infusion led to an improvement of left ventricular (LV) ejection fraction, myocardial ventilation oxygen consumption, 6-min walk distance, and quality of life [50]
How do GLP-1 receptor agonists affect heart rate and blood pressure
Subsequent studies also examining data from the FDA Adverse Event Reporting System (FDA AERS) reported an increase in reporting rates of PDAC cases in GLP-1RA users over a broader study period 33,34
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