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Interestingly, RANTES and its receptor CCR5 are important mediators of obesity-induced inflammation, which was shown in CCR5-KO mice (91)

Our results indicate that clinically used type 2 diabetes treatments could be employed in a preventive role to improve stroke outcome by exerting dual pharmacological action: weight loss and acute neuroprotection

Bramante, C

We have also heard of women who lost weight only to have their insurance company discontinue coverage
Historically, poor outcomes were often attributed to nonadherence
