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Supporting this possibility, preclinical studies have reported that setmelanotide can effectively restore MC4R activity in obese animal models harboring LOF MC4R variants, thereby reducing food intake and increasing total energy expenditure, which results in significant weight loss
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Clean the injection site with an alcohol swab, pinch the skin to create a fold, insert the needle at a 45-90 degree angle, slowly inject the solution, then withdraw the needle and apply gentle pressure to the site
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