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Other observational studies have linked GLP-1 drugs to lower rates of new and recurring alcohol use disorder, reduced diagnoses and relapse in cannabis use disorder, fewer health care visits for nicotine dependence and lower risk of opioid overdose

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More rare but serious gastrointestinal side effects include stomach paralysis and intestinal obstruction

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GLP-1RAs also reduce intracranial pressure and alleviate headache symptoms associated with conditions like idiopathic intracranial hypertension, particularly in female patients [98101]