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13 In addition to being recommended in patients with ASCVD, GLP-1 receptor agonists are recommended for consideration as an add-on to metformin in patients without established ASCVD in whom there is a compelling need to minimize hypoglycemia, minimize weight gain, or promote weight loss

It also makes it harder for your PlexusDx provider to assess your dose effectiveness

They require prescriptions from licensed providers

While uncomfortable, its generally a temporary response as your body adjusts to the medication