soul trial oral semaglutide cardiovascular outcomes trial results Reduces CV Events in T2DM – (NEJM, Mar 2025) Relevant for: cardiology, diabetology, nephrology, internal medicine 🧪 T2DM + ASCVD/CKD 💊 Oral semaglutide 14 mg vs placebo 📉 Cardiovascular outcomes of semaglutide and

The IRR was 0.62 (95% CI: 0.400.95), and adjusted analyses indicated that people receiving semaglutide were significantly less likely to experience a stroke event than those receiving a DPP4i (HR: 0.63 [0.410.95]

Leptin, produced by fat tissue, supports trophoblastic cell growth and early pregnancy processes, so very low or very high levels can both be an issue

Many people find the stomach area to be the most convenient, but the thigh and upper arm are also good options

Monitoring the response with repeat hormone panels is essential to determining whether the approach is delivering adequate clinical benefit or whether TRT is more appropriate

A licensed provider can help monitor: side effects dose escalation treatment response medication tolerance overall treatment goals Patients should avoid purchasing medications from unsafe or unverified online sources