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Medication Mechanism of Action Average Weight Loss Retatrutide Triple agonist (GLP-1, GIP, Glucagon) Up to 24% average weight loss over 48 weeks Semaglutide GLP-1 receptor agonist Up to 17% over 68 weeks Tirzepatide Dual agonist (GLP-1, GIP) Up to 25% over 52 weeks Retatrutide is used to help with weight loss

Prediction markets and analyst estimates As of early 2026, prediction markets place the probability of FDA approval this year at approximately 27%

Lancet Diabetes Endocrinol 2020;8:447-55

Market Launch Eli Lilly will begin ramping production after approval, which can take 2 to 4 months

This can be a game-changer for weight management, especially for Goodlettsville residents seeking effective solutions