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In CVOTs, liraglutide, semaglutide and dulaglutide demonstrated appreciable cardiovascular and renal protective effects, among which liraglutide had an appreciable effect on mitigating the risk of cardiovascular death [4], while semaglutide and dulaglutide conferred a risk reduction on non-fatal stroke [22, 23]

the STEP 5 trial represents the most extensive study on the use of semaglutide for weight management to date

Batchuluun B, Pinkosky SL, Steinberg GR

Clinical data from multiple trials shows that extending beyond 4 weeks offers no additional tolerability benefit while unnecessarily delaying therapeutic effect

However, comprehensive data on the direct effects of HF are still being developed (NCT04847557)