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Lower calorie intake can also influence energy levels

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SLU-PP-332 gained significant research attention following a 2023 publication in the Journal of Medicinal Chemistry (Ping et al., Washington University) demonstrating that the compound increased running endurance in mice by approximately 70% without training, alongside upregulation of mitochondrial biogenesis markers (PGC-1, TFAM) and oxidative fiber gene expression in skeletal muscle

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The control group included patients with IBS-D who were never prescribed antidepressants or IBS-D medications

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