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Participants received diet (500kcaldeficit per day) and exercise counseling during 2-week run-in, before being randomly assigned (with a telephone or web-based system) to once-daily subcutaneous liraglutide (1.2, 1.8, 2.4 or 3.0mg, n=9095), placebo (n=98) or open-label orlistat (120mg 3, n=95)

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GLP-1 medications, initially developed to manage type 2 diabetes, have gained recognition as effective tools for weight loss

Cagrilintide GLP-1 C 5mg (Lyophilized Peptide) For Research Use Only For laboratory research use only

Each vial contains 2mg of semaglutide, designed for subcutaneous injection