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Liraglutide was discontinued, topical agents were initiated, but she failed to respond

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JAMA 312:26682675 UK Prospective Diabetes Study (UKPDS) Group (1998) Effect of intensive blood glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

For diabetic patients, however, ongoing use may remain necessary for insulin management. Concerns about diminishing effectiveness over time, Schmidt believes, are often overstated

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