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While the study did not include follow-up ICP measurements, the reduction in the Frisen grade and retinal nerve fiber layer (RNFL) thickness served as surrogate markers for ICP reduction

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The data reveals a dose-response relationship between Retatrutide and autonomic suppression: At the highest dose (8mg), my HRV hit rock bottom at 24ms with resting heart rate climbing to 67 bpm

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Tirzepatide, a dual GLP-1 and GIP receptor agonist, showed even greater weight reduction in the SURMOUNT trials, with some participants achieving 22% body weight loss