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Indeed, an important issue for the potential cognitive and mental health effects of GLP-1RAs, which our analysis cannot fully address, is whether these medications provide symptomatic relief only via their well-established cardiometabolic benefits, or by directly targeting physiopathological mechanisms behind cognitive and mental symptoms

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Documented Outcomes Prescription semaglutide and tirzepatide have undergone Phase 3 randomized controlled trials demonstrating average weight loss of 10-22 percent over 68 weeks

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