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Persistently elevated concentrations of CRP, TNF-, and IL-6 contribute directly to insulin resistance through serine phosphorylation of IRS-1, impair vascular endothelial function through suppression of endothelial nitric oxide synthase (eNOS) activity, and accelerate the progression of macrovascular disease through promotion of atherogenic lipid modification, foam cell formation, and plaque instability

[PubMed] Mller TD, Finan B, Bloom SR, et al

Regular blood sugar monitoring is crucial, especially if early warning signs are subtle or absent

In fact, pharmacological blockade of GLP-1R that is ineffective in sham rats, restores the chow intake of Roux-en-Y gastric (RYGB) operated rats (Abegg et al., 2013)

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