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The potential for harm is even greater if a treatment with the same rate of adverse events was applied to the nearly 50 million people estimated to be living with preclinical disease (i.e., people with AD pathology but who remain asymptomatic) (Brookmeyer and Abdalla, 2018

adults classified as obese and overweight was obtained from the National Health and Nutrition Examination Survey (NHANES), a project of the Centers for Disease Control and Prevention

These medications work through different mechanisms to control blood sugar - metformin reduces glucose production in the liver and improves insulin sensitivity, while Ozempic helps the pancreas release insulin and reduces appetite [2]

Wegovy is indicated for chronic weight management, while Ozempic is indicated for type 2 diabetes treatment and may only be prescribed off-label for weight management by qualified healthcare providers within their medical judgment

Without the ability to demonstrate target engagement, it can be challenging to know why a trial failed