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It can elevate blood pressure and heart rate, and it can make people feel irritable

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doi: 10.1186/s13287-020-01689-5 142 WuAYPeeblesRS

Calculating Your Personalized Calorie Target on Semaglutide A practical starting framework uses your basal metabolic rate (BMR) minus 500750 calories daily

There is reasonable scientific basis to expect that the GLP-1 component will confer similar cardiovascular protection
