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Barry MJ, Williford WO, Chang Y, Machi M, Jones KM, Walker-Corkery E, Lepor H (1995) Benign prostatic hyperplasia specific healthy status measures in clinical research: how much change in the American Urological Association Symptom Index and the Benign Prostatic Hyerplasia Impact Index is perceptible to patients

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Every time you puncture that stopper with a needle, you create a tiny channel that can allow air to enter the vial

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