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Your provider adjusts your dose over time based on your tolerance, side effects, and weight loss progress

Side effects improve significantly over time Second Natures research showed that side effects decrease substantially as the body adjusts to the medication: 3 Nausea dropped from 31.5% to 3.1% (semaglutide) and 27.8% to 10.5% (tirzepatide) by month 12 Fatigue dropped from 24.6% to 3.1% (semaglutide) and 21.5% to 8.1% (tirzepatide) by month 12 The proportion reporting no side effects increased significantly in both groups Hair loss: what the research shows Hair loss is often reported as a concern with weight-loss medications

It works by mimicking the effects of the natural GLP-1 hormone in your body

Retrieved 7 June 2025

The feeling of fullness can extend to liquids, and mild, persistent nausea can make the thought of drinking unappealing