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(2) RCTs completed before the FDA guidance of 2008 [17] and (3) follow-up duration of at least 6 months

The FDA label requires at least 4 weeks at 2.4 mg before stepping up

Alzheimer's disease affects women at roughly twice the rate of men, and the hormonal biology of menopause is increasingly understood as a contributing factor to that disparity, not merely a coincidence of longer average lifespan [3]

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Approximate dose equivalencies These are rough approximations
