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Comparing Compounded Semaglutide to Brand-Name Wegovy in the First Month Compounded semaglutide from licensed 503A pharmacies contains the same active ingredient as Wegovy and works through identical mechanisms, meaning first-month weight loss trajectories are comparable when doses are matched

Patients in trials get the drug at no cost, but they may receive placebo, and they have to meet specific inclusion criteria (often a body mass index (BMI) of 30 or higher, or 27 with a related condition)

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Medicines with a narrow therapeutic index where small changes in blood concentration can have significant clinical consequences merit particular attention