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The SURMOUNT-1 trial showed approximately 20.9% average body weight reduction at 72 weeks under controlled conditions with the highest dose of FDA-approved tirzepatide

10.3390/nu13103480 Nutrients 116 WangK.LiM.JinL.DengC.ChenZ.ChenH.et al (2019)

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It is a paper that says the muscle loss is real but not disproportionate, not pathological, and not a reason to avoid these medications
