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Increased expression and release of proinflammatory cytokines (TNF-, IL-1, and IL-6) have been described both in vitro and in vivo [156]

This mechanism explains why some patients experience heartburn or acid regurgitation shortly after starting GLP-1 therapy

[DOI] [PubMed] [Google Scholar] 31.Genovese S., Mannucci E., Ceriello A

Most patients will experience a gradual waning of therapeutic benefits over 1-2 weeks after the last injection, though this can vary between individuals

Moreover, tirzepatide leads to a reduction in liver fat, macroalbuminuria, blood pressure, and lipids [13]
