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On the latter, studies conducted using site-specific brain micro-injections and single-photon emission computed tomography documented a novel regulatory role of the hypothalamic supramammillary nucleus in the regulation of food intake and reward, posing this brain area as one of the main targets of the GLP1/E conjugate, along with the lateral hypothalamus and the nucleus of the solitary tract, whose activation may be responsible for the anorectic, weight-lowering and reward reducing effects of this multi-agonist 51

[DOI] [PMC free article] [PubMed] [Google Scholar] [29].Romero-Zerbo SY, Garca-Fernndez M, Espinosa-Jimnez V, Pozo-Morales M, Escamilla-Snchez A, Snchez-Salido L, et al

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The loss of fat from the face can make the skin appear loose or aged