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Increased cytoplasmic Ca +2 triggers mitochondrial ATP generation and insulin exocytosis from insulin granules
In a similar model, intrathecal injections of exenatide inhibited thermal hyperalgesia and mechanical allodynia by enhancing spinal microglial expression of -endorphins, IL-10 and interleukin 4 (IL-4) [34, 35]

Nora Volkow, director of the National Institute on Drug Abuse at the National Institutes of Health, who has done similar work analyzing medical records to assess GLP-1 drugs
