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By leveraging the high expression level of the Alb gene in hepatocytes, we targeted the Alb locus for the knock-in of the secretable Exe4

As a result, many patients do not fully respond to available therapies, highlighting the urgent need for more targeted, personalized treatment strategies that address the multifactorial pathogenesis of HS

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Appetite changes Some community users report appetite changes, though food intake was not significantly altered in the DIO mouse studies