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Therapeutic Approaches to Enhance GLP-1 Activity Two pharmacological strategies are available to enhance GLP-1 signalling: DPP-4 Inhibitors Mechanism: Inhibit dipeptidyl peptidase-4 (DPP-4), the enzyme responsible for degrading endogenous GLP-1

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The fourfold table, equations and criteria of the four disproportionality algorithms for tirzepatide signal detection are shown in Supplementary Tables S1-S2

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