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Many patients with obesity are now managing their condition with a primarily pharmacological approach
On the other hand, new evidence has demonstrated that GLP-1 agonism also plays a key role in glial cells, thus, astrocytes in the NTS (solitary nucleus) could regulate the central effects of GLP-1 controlling the energy balance, as demonstrated by the pharmacological inhibition of NTS astrocytes attenuating the anorectic and body-weight-suppressive effects on intra-NTS GLP-1R activation [103]
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