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The GLP-1 agonists were initially used to help treat diabetes but doctors noticed that weight-loss was useful side-effect for many patients and the medication was then adapted to be used for weight loss in its own right

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The first cohort included 6696 patients who started GLP-1 receptor agonists and added on SGLT-2 inhibitors, and the second included 8942 patients who started SGLT-2 inhibitors and added on GLP-1 receptor agonists

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