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5 Even modest weight loss is clinically meaningful: reductions of 5% of baseline weight can improve blood pressure, glucose levels and cardiovascular risk

Importantly, these mechanistic hypotheses are supported by evidence from large, randomised controlled trials, which has demonstrated that GLP-1RAs reduced major adverse cardiovascular events (MACE), including myocardial infarction, stroke and cardiovascular death, particularly in high-risk individuals such as those with type 2 diabetes mellitus

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