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Cachexia is a multifactorial metabolic syndrome, characterized by weight loss and skeletal muscle loss caused by underlying diseases such as cancer, heart failure and renal failure [5]

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Increasing cAMP Production in Response to Metformin-Induced GLP-1 and GIP MIN6 cells were treated with 10 nM GLP-1 or GIP in the presence of 5.5 or 16.7 mM glucose, and cAMP production was monitored for 40 min (Figures 1(a) and (b))