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Description
Partial Agonism and Signaling Bias Orforglipron functions as a partial agonist at the GLP-1 receptor, meaning it produces submaximal activation compared to full agonists such as native GLP-1 or semaglutide

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Some studies have also documented improvements in markers of endothelial dysfunction and oxidative stress, processes intimately linked with vascular inflammation

doi: 10.1002/oby.22051
