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doi: 10.1073/pnas.1711233114 [DOI] [PMC free article] [PubMed] [Google Scholar] 222
Dosing starts low, typically 0.25 mg weekly, and titrates upward over the first few months toward a steady maintenance dose of up to 2.4 mg, paced to your tolerance

These low doses help your body adjust and reduce the risk of possible gastrointestinal side effects such as nausea, vomiting, diarrhea and constipation
The expected weight loss timeline varies by individual, and slower progress does not necessarily mean the dose needs increasing

doi: 10.1007/s00592-020-01568-8
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