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People using these medicines can lose more weight than with diet and exercise alone a loss of between 5% and 21% of their body weight can be expected depending on which medicine is taken and how long it is used

Following the predefined inclusion and exclusion criteria, 36 studies were included in this systematic review and underwent qualitative analysis

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The protective effect was seen across a wide variety of addictive and habit-forming substances, including cocaine, opioids, alcohol, nicotine and cannabis.

Summary Integrating emerging mechanistic and clinical observations, this review synthesizes current evidence from a metabolic flux perspective