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Gastrointestinal Adverse Effects of GLP-1 and Dual GLP-1/GIP Receptor Agonists: A Comprehensive Update in Diabetic and Obese Populations

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Introduction: The Global Health Challenge Redefining Drug Delivery The convergence of the global obesity and type 2 diabetes (T2D) epidemicsa condition often termed diabesity represents one of the most pressing public health challenges of our time

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Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, inhibition of food intake, increase of natriuresis and diuresis, and modulation of rodent -cell proliferation