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Available from: Accessed: 10 Jun 2025 Congressional Budget Office (2021) Research and development in the pharmaceutical industry

Hikma Pharmaceuticals), a glucagon-like peptide-1 (GLP-1) receptor agonist indicated to improve glycemic control in adults and pediatric patients aged 10 years and older with type 2 diabetes

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It is reasonable to plan treatment based on steady losses but if a practitioner suspects that weight loss will be extreme, or alternatively that weight will actually be gained rather than lost, aesthetic outcomes may be compromised

Acute or tissue-restricted APJ activation may be appropriate for cardiometabolic indications, whereas chronic systemic exposure may be unsuitable without biased or targeted agonists