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These effects are usually temporary and subside as your body adjusts

Acute exenatide has been reported to inhibit cocainestimulated locomotor hyperactivity and decrease or abolish cocaineinduced dopamine release in the NAc and lateral septum in mice (Egecioglu, Engel, & Jerlhag, 2013a

Anthropometrical measurements taken to the participants included weight, height, waist and hip circumferences and bioimpedance analysis (InnerScan BC-545

Neuronal and intracellular signaling pathways mediating GLP-1 energy balance and glycemic effects

Beyond hormonal changes, several interconnected factors may contribute to perimenopausal weight gain: Metabolic slowdown : Basal metabolic rate naturally decreases with age, meaning the body burns fewer calories at rest Muscle mass loss : Sarcopenia (age-related muscle loss) accelerates during perimenopause, further reducing metabolic rate Sleep disruption : Night sweats and insomnia, common perimenopausal symptoms, interfere with hormones regulating appetite and glucose metabolism Mood changes : Anxiety, depression, and stress during this transition may lead to emotional eating patterns Reduced physical activity : Fatigue, joint pain, and other symptoms may decrease exercise tolerance Research suggests women may gain weight gradually during perimenopause, though individual experiences vary considerably