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Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetes

Over time, with gradual decline in -cell function or mass, dysglycaemia sets in (stage 2)

Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, Silverman MG, Zelniker TA, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Ruff CT, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde AM, Sabatine MS

However, the included studies generally lacked sufficient detail regarding these concurrent interventions, making it difficult to fully assess their potential impact on the outcomes

It plays an important role in controlling appetite, digestion, and overall metabolic function