tirzepatide lowers inflammation The promise of tirzepatide: A narrative review of metabolic benefits How Tirzepatide Helps Lose Weight

Semaglutide reduces systemic inflammation and improves metabolic markers, which can theoretically support better skin health, but these effects work slowly over months

There is also a stacking effect to keep in mind

Under-fueling: Eating far too few calories or inadequate protein can cause profound fatigue and severe chills as your body struggles to generate basic metabolic heat

It can also signal to the brain to reduce appetite and make you feel full, as well as slow transit of food through your gut, Alan says

Dual Agonist Semaglutide works as a GLP-1 receptor agonist (activator) , which means it mimics the activity of glucagon-like peptide-1, a hormone that your gut generates naturally after eating